From Genes to Treatments: The Role of  Genes SERT, DRD2, CHRNA5, and CYP2A6 in Nicotine Craving and Control

Authors

  • Seyed Ali Hosseini
  • Ali Aghajan
  • Kimia Parvardeh
  • Seyed Ali Alavi
  • Hamed Hekmatnezhad Department of Basic Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Iran https://orcid.org/0000-0002-5716-9240

DOI:

https://doi.org/10.61882/jcbior.6.1.288

Keywords:

Gene Polymorphism, Nicotinic Receptor, Smoking, CYP2A6 Gene, CHRNA5 Gene

Abstract

without Abstract

Author Biography

  • Hamed Hekmatnezhad, Department of Basic Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Iran
     

    Email:

    hamed_hekmatnezhad@jcbior.com

    hamedhekmatnejad@yahoo.com

     

     

References

1. Liang Y, Ou J, Fu J, Wang Y, Li Y, Li J, Yi Y. Smoking, Genetic Susceptibility and Early Menopause: Unveiling Biological Mechanisms and Potential Therapy Targets. BJOG. 2025; 132(5):625-637. DOI: 10.1111/1471-0528.18052 PMID: 39727065

2. Jones SK, Alberg AJ, Wallace K, Froeliger B, Carpenter MJ, Wolf BJ. CHRNA5-A3-B4, CYP2A6, and DBH Genetic Associations With Smoking Cessation Throughout Adulthood Within Two Longitudinal Studies of Women. Nicotine Tob Res. 2025;27(6):970-979. DOI: 10.1093/ntr/ntae284 PMID: 39673390

3. Jones SK, Alberg AJ, Wallace K, Froeliger B, Carpenter MJ, Wolf BJ. CHRNA5-A3-B4, CYP2A6, and DBH Genetic Associations With Smoking Cessation Throughout Adulthood Within Two Longitudinal Studies of Women. Nicotine Tob Res. 2025;27(6):970-979. DOI: 10.1093/ntr/ntae284 PMID: 39673390

4. Chenoweth MJ, Lerman C, Knight J, Tyndale RF. Influence of CYP2A6 Genetic Variation, Nicotine Dependence Severity, and Treatment on Smoking Cessation Success. Nicotine Tob Res. 2023;25(6):1207-1211. DOI: 10.1093/ntr/ntac268 PMID: 36789481

5. Muenstermann C, Clemens KJ. Epigenetic mechanisms of nicotine dependence. Neurosci Biobehav Rev. 2024;156:105505. DOI: 10.1016/j.neubiorev.2023.105505 PMID: 38070842

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Published

2025-03-30

Issue

Section

Letter

How to Cite

From Genes to Treatments: The Role of  Genes SERT, DRD2, CHRNA5, and CYP2A6 in Nicotine Craving and Control. (2025). Journal of Current Biomedical Reports, 6(1), 25-26. https://doi.org/10.61882/jcbior.6.1.288

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